The primary end points in the MD1003 trial are EDSS and TW25. I don't really want to use those as end points. A couple of metrics that may make sense to me might be:
- time to claw foot during soccer games. My right foot tends to make a fist when I'm playing soccer after the first few minutes. At the point that this happens my balance and leg strength is also deteriorating. Typically I play well for the first 5 - 15 minutes before things start to go downhill.
- distance to vibrating legs on the stationary bike. I typically ride 2 - 4 miles on the stationary bike but my legs start to vibrate about 1 - 2.5 miles in. For the remainder of the ride I push down on my knees with my hands to steady them.
- others tbd