Wednesday, April 15, 2015

Metrics

The primary end points in the MD1003 trial are EDSS and TW25.  I don't really want to use those as end points.  A couple of metrics that may make sense to me might be:

- time to claw foot during soccer games.  My right foot tends to make a fist when I'm playing soccer after the first few minutes.  At the point that this happens my balance and leg strength is also deteriorating.  Typically I play well for the first 5 - 15 minutes before things start to go downhill.

- distance to vibrating legs on the stationary bike.  I typically ride 2 - 4 miles on the stationary bike but my legs start to vibrate about 1 - 2.5 miles in.  For the remainder of the ride I push down on my knees with my hands to steady them.

- others tbd

37 comments:

  1. baseline rowing speed 4:00 per 100 stokes at a tension of 10. Range 3:15 - 4:45 per 100. Sessions 300 - 750 stokes. 5-6 x per week. 700+ means no bike that day.

    Baseline biking speed 6:00 per mile at a tension of 5.5. Range 5:30 - 6:45 per mile. Sessions 2-5 miles (5 miles means no rowing that day). 5-6 times per week.

    These times have stabilized after improvement in the first few months. Significant improvement would be noteworthy.

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  2. Going to try median time for 1 legged stand. Here are the numbers for 4/16/15

    Right raw data 2.8, 3.3, 3.5 - median = 3.3
    Left raw data 1.9, 4.8, 3.9 - median = 3.9

    Holding phone stopwatch while measuring

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  3. Data for 4/17/15

    Right 1.9, 3.1, 3.9 - 3.1
    Left 3.6, 2.8, 3.9 - 3.6

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  4. At 9 months I'll look for 20% improvements in at least one of the three metrics discussed

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  5. This means 18 minutes to claw foot / deterioration in soccer performance, 3 miles without vibrating leg on the bike.

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  6. The 1 leg stand times (median) will be plotted and examined for 20% improvement over the course of 9 months in the best fit trend line.

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  7. Numbers for 4/18/15

    R- 3.5, 0.9, 2.3 - 2.3
    L- 3.2, 3.9, 3.7 - 3.7

    If these end up being an outlier possible root cause is moving sofa for Dayna's mom

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  8. Numbers for 4/20/15

    R - 1.6, 1.9, 1.5 - 1.6
    L - 1.5, 2.8, 3.8 - 2.8

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  9. 4/22/15

    R - 2.4, 3.7, 2.8 - 2.8
    L - 2.7, 2.6, 2.9 - 2.7

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  10. April 24

    R - 2.8, 4.2, 3.7 - 3.7
    L - 2.9, 3.2, 2.9 - 2.9

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  11. Had a REALLY good soccer game today. Could be coincidence, could be placebo, or ...?

    Anyhow - feeling very encouraged

    ( :

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  12. 4/25/15

    R - 2.4, 5.3, 4.8 - 4.8
    L - 4.9, 5.2, 6.1 - 5.2

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  13. L - 5.0, 5.6, 7.8 - 5.6
    R - 2.4, 3.5, 3.8 - 3.5

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  14. R - 4.2, 6.7, 2.8 - 4.2
    L - 3.0, 6.5, 2.5 - 3.0

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  15. L - 10.2, 7.1, 5.0 - 7.1
    R - 4.2, 4.6, 4.4 - 4.4

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  16. L - 4.8, 2.4, 11.4 - 4.8
    R - 7.3, 2.9, 2.9 - 2.9

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  17. R - 2.4, 4.8, 2.8 - 2.8
    L - 2.2, 5.2, 11.2 - 5.2

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  18. L - 3.1, 8.4, 6.0 - 6.0
    R - 2.0, 4.3, 2.8 - 2.8

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  19. Right leg values lower than left consistent with right leg first to get shaky during the day.

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  20. R - 4.1, 4.5, 2.8 - 4.1
    L - 4.0, 5.6, 4.2 - 4.2

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  21. L - 6.2, 2.6, 4.8 - 4.8
    R - 3.1, 2.6, 3.6 - 3.1

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  22. R - 2.8, 4.5, 2.3 - 2.8
    L - 18.5, 4.5, 7.5 - 7.5

    This was the first time I thought maybe I should pause between measurements and fatigue may have been distinguishable from balance. I didn't pause though. For sake of consistency I wont pause.

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  23. R - 3.6, 2.9, 4.8 - 3.6
    L - 13.8, 10.0, 13.6 - 13.6

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  24. R - 4.0, 2.8, 2.6
    L - 7.2, 14.1, 10.9

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  25. L - 10.2, 9.4, 11.3
    R - 9.7, 5.3, 2.9

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  26. R - 2.8, 2.8, 7.5
    L - 3.6, 15.7, 15.5

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