The primary end points in the MD1003 trial are EDSS and TW25. I don't really want to use those as end points. A couple of metrics that may make sense to me might be:
- time to claw foot during soccer games. My right foot tends to make a fist when I'm playing soccer after the first few minutes. At the point that this happens my balance and leg strength is also deteriorating. Typically I play well for the first 5 - 15 minutes before things start to go downhill.
- distance to vibrating legs on the stationary bike. I typically ride 2 - 4 miles on the stationary bike but my legs start to vibrate about 1 - 2.5 miles in. For the remainder of the ride I push down on my knees with my hands to steady them.
- others tbd
baseline rowing speed 4:00 per 100 stokes at a tension of 10. Range 3:15 - 4:45 per 100. Sessions 300 - 750 stokes. 5-6 x per week. 700+ means no bike that day.
ReplyDeleteBaseline biking speed 6:00 per mile at a tension of 5.5. Range 5:30 - 6:45 per mile. Sessions 2-5 miles (5 miles means no rowing that day). 5-6 times per week.
These times have stabilized after improvement in the first few months. Significant improvement would be noteworthy.
Going to try median time for 1 legged stand. Here are the numbers for 4/16/15
ReplyDeleteRight raw data 2.8, 3.3, 3.5 - median = 3.3
Left raw data 1.9, 4.8, 3.9 - median = 3.9
Holding phone stopwatch while measuring
Data for 4/17/15
ReplyDeleteRight 1.9, 3.1, 3.9 - 3.1
Left 3.6, 2.8, 3.9 - 3.6
At 9 months I'll look for 20% improvements in at least one of the three metrics discussed
ReplyDeleteThis means 18 minutes to claw foot / deterioration in soccer performance, 3 miles without vibrating leg on the bike.
ReplyDeleteThe 1 leg stand times (median) will be plotted and examined for 20% improvement over the course of 9 months in the best fit trend line.
ReplyDeleteNumbers for 4/18/15
ReplyDeleteR- 3.5, 0.9, 2.3 - 2.3
L- 3.2, 3.9, 3.7 - 3.7
If these end up being an outlier possible root cause is moving sofa for Dayna's mom
Numbers for 4/20/15
ReplyDeleteR - 1.6, 1.9, 1.5 - 1.6
L - 1.5, 2.8, 3.8 - 2.8
4/22/15
ReplyDeleteR - 2.4, 3.7, 2.8 - 2.8
L - 2.7, 2.6, 2.9 - 2.7
April 24
ReplyDeleteR - 2.8, 4.2, 3.7 - 3.7
L - 2.9, 3.2, 2.9 - 2.9
Had a REALLY good soccer game today. Could be coincidence, could be placebo, or ...?
ReplyDeleteAnyhow - feeling very encouraged
( :
4/25/15
ReplyDeleteR - 2.4, 5.3, 4.8 - 4.8
L - 4.9, 5.2, 6.1 - 5.2
L - 5.0, 5.6, 7.8 - 5.6
ReplyDeleteR - 2.4, 3.5, 3.8 - 3.5
R - 4.2, 6.7, 2.8 - 4.2
ReplyDeleteL - 3.0, 6.5, 2.5 - 3.0
L - 10.2, 7.1, 5.0 - 7.1
ReplyDeleteR - 4.2, 4.6, 4.4 - 4.4
L - 4.8, 2.4, 11.4 - 4.8
ReplyDeleteR - 7.3, 2.9, 2.9 - 2.9
R - 2.4, 4.8, 2.8 - 2.8
ReplyDeleteL - 2.2, 5.2, 11.2 - 5.2
L - 3.1, 8.4, 6.0 - 6.0
ReplyDeleteR - 2.0, 4.3, 2.8 - 2.8
Right leg values lower than left consistent with right leg first to get shaky during the day.
ReplyDeleteR - 4.1, 4.5, 2.8 - 4.1
ReplyDeleteL - 4.0, 5.6, 4.2 - 4.2
L - 6.2, 2.6, 4.8 - 4.8
ReplyDeleteR - 3.1, 2.6, 3.6 - 3.1
R - 2.8, 4.5, 2.3 - 2.8
ReplyDeleteL - 18.5, 4.5, 7.5 - 7.5
This was the first time I thought maybe I should pause between measurements and fatigue may have been distinguishable from balance. I didn't pause though. For sake of consistency I wont pause.
R - 3.6, 2.9, 4.8 - 3.6
ReplyDeleteL - 13.8, 10.0, 13.6 - 13.6
L - 27.2, 2.5, 5.1
ReplyDeleteR - 2.9, 2.6, 4.9
R - 2.7, 5.5, 3.8
ReplyDeleteL - 4.2, 5.8, 9.9
L - 4.5, 9.1, 13.5
ReplyDeleteR - 2.0, 7.0, 9.7
R - 2.1, 4.2, 5.1
ReplyDeleteL - 5.8, 6.1, 20.4
L - 12.2, 4.5, 6.5
ReplyDeleteR - 2.2, 2.2, 4.5
R - 4.0, 2.8, 2.6
ReplyDeleteL - 7.2, 14.1, 10.9
L - 2.5, 6.5, 5.3
ReplyDeleteR - 1.8, 3.5, 4.6
R - 1.9, 5.0, 2.9
ReplyDeleteL - 5.2, 4.9, 18.5
L - 10.2, 9.4, 11.3
ReplyDeleteR - 9.7, 5.3, 2.9
R - 3.5, 3.7, 3.3
ReplyDeleteL - 5.5, 4.9, 6.7
R - 2.8, 2.8, 7.5
ReplyDeleteL - 3.6, 15.7, 15.5
L 6.4
ReplyDeleteR 5.6
L 11.8
R 6.1
L 11.5
R 5.9
L 15
ReplyDeleteR 5
L 9
R 4
L 5
R 3
L 6
ReplyDeleteR 4
L 7
R 3
L 4.5
R 3.5