The Plan (reposted at day 52)

Trial plan:

·         Using 10,000 mcg (microgram) biotin from Natrol via Amazon.com
See Which biotin - now using Natures bounty exclusively.  It is d-biotin, calcium free, $9 per 6 day supply (120 x 10 mg is 6 days per my protocol).

·         Taking biotin with Swiss chard (just a pinch) or peanuts sunflower seeds (just a few)

·         1 unit once per waking hour

o   Or 2 units per 2 hours if necessary, always with biotin containing food

·         1-2 units if I wake up in the middle of the night for anything

·         Target 15 – 20 units daily (19 - 21 units daily so far)

·         Maintain this plan for at least 12 months

·         Keep a log of actuals – recognizing that this is a difficult plan to adhere to

Rationale:

·         Patent based on 100 mg – 600 mg daily was well tolerated, therefor 200 mg should be safe

o   Biotin is water soluble and doesn’t build up in the body – excess will be excreted

o   Results were seen in case studies as low as 100 mg daily, most patients were given 300 mg

o   150-200 at the suggested interval most likely as effective as 300 in 3 daily doses

·         Half-life of biotin is 2 hours – that is why the frequent distributed dosing schedule

·         Food containing biotin most likely also contain elements that aid in the body’s absorption of biotin

o   Peanuts, swiss chard, egg yolks (but egg yolks contain saturated fat which is contra-indicated for MS)

·         Patients took 2 – 12 months to see results.  Will commit to this study for 12 months

o   Patients had very advanced progressive MS and still saw improvements – very exciting research geared towards recovering lost function

Considerations:

·         All indications are that this is safe.  Still – we are talking about hundreds or thousands of times the daily recommendation for Biotin

·         I’ve estimated cost to be around $45 per month.

o   There is a cheaper but less convenient and safe way to do this

o   Bulk pharmaceutical grade biotin is available for $166 / kg which would last more than a year at this dosing plan

o   This is less safe and less accurate and only saves $384 over the course of a year.  I don’t recommend it.